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Polymorphism in the pharmaceutical industry by Rolf Hilfiker

Polymorphism in the pharmaceutical industry Rolf Hilfiker ebook
Format: pdf
Publisher: Wiley-VCH
ISBN: 3527311467, 9783527311460
Page: 433

Case Studies from the Pharmaceutical Industry. Integrated Process Research and Development by Solvias: Basis of an Efficient and Successful Drug Substance Development in the Pharma Industry. Thermodynamics of Polymorphism. Lack of control could be due to variation in particle sizes or to changes in crystallinity (i.e. He points out that pioneer companies, those who first create the pharmaceutical product widely claim that patent claims for novel crystal forms is an important component of their intellectual property position, but that it significantly delays the entry of generic versions of drugs once “There are numerous instances where innovator companies have acquired patents on a particular polymorphic form,” says Vure, “which extend beyond the expiry of basic molecule's patent. A chronicle of human rights violations and crimes by the psychiatric industry (by Philip) The giant pharmaceutical companies lurk at the centre of a world wide web of deception and corruption. Thermodynamics versus Kinetics and the Formation of Polymorphs. What are some of the applications of crystal engineering? It is well-known that calcium atorvastatin (ATV), C66H68CaF2N4O10•3H2O, presents polymorphism. This training is being organized jointly by Shanghai Institute of Pharmaceutical Industry (SIPI), Shanghai Eterpharm Inc., and METTLER TOLEDO. Applied catalysis, which is directed at developing novel catalysts and processes relevant to the petrochemical, fine chemical and pharmaceutical industries 2. On the other side of the opinion aisle, PhRMA, the trade association for the pharmaceutical industry, contributed its own hysteria. It is an unfortunate reality that with so much disinformation being spread by the media, the medical establishment, and the pharmaceutical industries, it is becoming more and more difficult to take at face value anything that comes out of their mouths. While genetic variants in pharmacokinetic structures exert effects on drug efficacy via the differences in drug exposure, polymorphisms in drug targets can directly affect clinical efficacy and may lead to a broad variation spectrum between inefficacy and severe side effects. Now, we are focusing on polymorphism and pseudo polymorphism, which is not only an academic challenge, but has great relevance for the pharmaceutical industry. "PhRMA is very disappointed with the Indian Supreme Court's decision to deny a patent on It's not sexy, but the guts of the decision came down to something called crystalline polymorphism--a fairly common phenomenon with solid chemicals. Methods of Polymorph Characterization. According to George Tranter from Chiralabs, “Crystallisation is one of the biggest problems of the pharmaceutical industry”. 8 years experience from pharmaceutical industry within the area of physical characterisation. Category: Drug Solid state investigations including salt selection, polymorphism screening, and crystallization optimization programs enable customers to prepare the optimal solid form of a drug substance with well-defined properties for manufacture of the corresponding drug product.